• Product NameMK-2206 dihydrochloride
• Brief DescriptionInhibitors
• Purification99.23%
• Biological ActivityMK-2206 2hydrochloride is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2
• Target NameAkt inhibitor
• CAS No. 1032350-13-2
• Calculated MW 480.39
• Formulation C25H23Cl2N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.Cl.NC1(CCC1)C1=CC=C(C=C1)C1=C(C=C2C3=NNC(=O)N3C=CC2=N1)C1=CC=CC=C1
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:Akt1; Akt2; Akt3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 14 mg/mL (29.14 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cheng Y, et al, Y Res, 2011, 71(7), 2654-2663.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting