• Product NameL-779,450
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityL-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
• Target NameRaf inhibitor
• CAS No. 303727-31-3
• Calculated MW 347.8
• Formulation C20H14ClN3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC1=C(Cl)C=CC(=C1)C1=C(NC(=N1)C1=CC=CC=C1)C1=CC=NC=C1
  Pathways:MAPK
  Receptor:Raf
  Boling pt:
  Melting pt:
  Solubility:DMSO: 34mg/mL
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shelton JG, et al. Leukemia. 2003 Sep;17(9):1765-82.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting