• Product NameSB225002
• Brief DescriptionInhibitors
• Purification98.39%
• Biological ActivitySB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.
• Target NameCXCR antagonist
• CAS No. 182498-32-4
• Calculated MW 352.14
• Formulation C13H10BrN3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O
  Pathways:Autophagy; GPCR/G Protein; Immunology/Inflammation
  Receptor:CXCR2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 3 mg/mL warmed (8.51 mM); DMSO: 70 mg/mL (198.78 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. White JR, et al. J Biol Chem. 1998, 273(17), 10095-10098.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting