• Product NameFR180204
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityFR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.
• Target NameERK inhibitor
• CAS No. 865362-74-9
• Calculated MW 327.34
• Formulation C18H13N7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:NC1=C2C=C(N=NC2=NN1)C1=C2C=CC=CN2N=C1C1=CC=CC=C1
  Pathways:MAPK
  Receptor:ERK1; ERK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL warmed (6.1 mM); DMSO: 65 mg/mL (198.57 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ohori M, et al. Biochem Biophys Res Commun. 2005, 336(1), 357-363.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting