• Product NameAZD2858
• Brief DescriptionInhibitors
• Purification99.25%
• Biological ActivityAZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, inhibits tau phosphorylation at the S396 site, activates Wnt signaling pathway.
• Target NameGSK-3 inhibitor
• CAS No. 486424-20-8
• Calculated MW 453.52
• Formulation C21H23N7O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1CCN(CC1)S(=O)(=O)C1=CC=C(C=C1)C1=CN=C(N)C(=N1)C(=O)NC1=CN=CC=C1
  Pathways:PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:GSK-3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 7 mg/mL (15.43 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sisask G, et al. Bone, 2013, 54(1), 126-132.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting