• Product NameAZ20
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM in a cell-free assay, 8-fold selectivity over mTOR.
• Target NameATM/ATR inhibitor; mTOR inhibitor
• CAS No. 1233339-22-4
• Calculated MW 412.51
• Formulation C21H24N4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATR; mTOR
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 3 mg/mL (7.27 mM); DMSO: 83 mg/mL (201.2 mM)
  Appearance:Off-white Color Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Xavier Jacq, et al. Y Res 2012;72(8 Suppl):Abstract nr 1823.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting