• Product NameBIX 01294 Trihydrochloride
• Brief DescriptionInhibitors
• Purification99.95%
• Biological ActivityBIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1392399-03-9
• Calculated MW 600.02
• Formulation C28H38N6O23HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.Cl.Cl.COC1=C(OC)C=C2C(NC3CCN(CC4=CC=CC=C4)CC3)=NC(=NC2=C1)N1CCCN(C)CC1
  Pathways:Chromatin/Epigenetic
  Receptor:G9a
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 8 mg/mL (13.33 mM); Water: 98 mg/mL (163.32 mM); DMSO: 98 mg/mL (163.32 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kubicek S, et al. Mol Cell, 2007, 25(3), 473-481.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting