• Product NameAZD2014
• Brief DescriptionInhibitors
• Purification98.29%
• Biological ActivityAZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ). Phase 2.
• Target NameAkt inhibitor; mTOR inhibitor; PI3K inhibitor; S6 Kinase inhibitor
• CAS No. 1009298-59-2
• Calculated MW 462.54
• Formulation C25H30N6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:P-Akt (S473); mTOR; PI3Kα; pS6 (S235/236)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 38 mg/mL (82.15 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sylvie M. Guichard, et al. Y Research: April 15, 2012; Volume 72, Issue 8, Supplement 1.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting