• Product NameINCB28060(Capmatinib)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCapmatinib (INCB28060) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Phase 1.
• Target Namec-Met/HGFR inhibitor
• CAS No. 1029712-80-8
• Calculated MW 412.42
• Formulation C23H17FN6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CNC(=O)C1=C(F)C=C(C=C1)C1=NN2C(CC3=CC4=C(C=C3)N=CC=C4)=CN=C2N=C1
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:c-Met
  Boling pt:
  Melting pt:
  Solubility:DMSO: 2 mg/mL (4.84 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liu X, et al, Clin Y Res, 2011, 17(227). 7127-7138.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting