• Product NameGedatolisib (PF-05212384, PKI-587)
• Brief DescriptionInhibitors
• Purification98.99%
• Biological ActivityGedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 1197160-78-3
• Calculated MW 615.73
• Formulation C32H41N9O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C)C1CCN(CC1)C(=O)C1=CC=C(NC(=O)NC2=CC=C(C=C2)C2=NC(=NC(=N2)N2CCOCC2)N2CCOCC2)C=C1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTOR; PI3Kα; PI3Kγ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 2 mg/mL (3.24 mM)
  Appearance:Gray Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Venkatesan AM, et al. J Med Chem. 2010, 53(6), 2636-2645.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting