• Product NameGSK 5959
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 901245-65-6
• Calculated MW 394.47
• Formulation C22H26N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=CC=CC=C1C(=O)NC1=C(C=C2N(C)C(=O)N(C)C2=C1)N1CCCCC1
  Pathways:Chromatin/Epigenetic
  Receptor:BRPF1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Demont EH, et al. ACS Med Chem Lett. 5(11):1190-1195.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting