• Product NamePFI-4
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 900305-37-5
• Calculated MW 380.44
• Formulation C21H24N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=CC=CC=C1C(=O)NC1=C(C=C2N(C)C(=O)N(C)C2=C1)N1CCCC1
  Pathways:Chromatin/Epigenetic
  Receptor:BRPF1; BRPF2; BRPF3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 50 mM
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Demont EH, et al. ACS Med Chem Lett. 5(11):1190-1195.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting