• Product NamePH797804
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay; 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.
• Target Namep38 MAPK inhibitor
• CAS No. 586379-66-0
• Calculated MW 477.3
• Formulation C22H19BrF2N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CNC(=O)C1=CC(N2C(C)=CC(OCC3=C(F)C=C(F)C=C3)=C(Br)C2=O)=C(C)C=C1
  Pathways:MAPK
  Receptor:p38α; p38β
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 7 mg/mL (14.66 mM); DMSO: 96 mg/mL (201.13 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hope HR, et al, J Pharmacol Exp Ther, 2009, 331(3), 882-895.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting