• Product NameBGJ398 (NVP-BGJ398)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.
• Target NameFGFR inhibitor
• CAS No. 872511-34-7
• Calculated MW 560.48
• Formulation C26H31Cl2N7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCN1CCN(CC1)C1=CC=C(NC2=CC(=NC=N2)N(C)C(=O)NC2=C(Cl)C(OC)=CC(OC)=C2Cl)C=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; FGFR2; FGFR3; FGFR3 (K650E); FGFR4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 1 mg/mL warmed (1.78 mM)
  Appearance:Off-white Color Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Guagnano V, et al. J Med Chem. 2011, 54(20), 7066-7083.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting