• Product NameRN486
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRN486 is a potent and selective BTK inhibitor with IC50 of 4 nM.
• Target NameBTK inhibitor
• CAS No. 1242156-23-5
• Calculated MW 606.69
• Formulation C35H35FN6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1CCN(CC1)C1=CN=C(NC2=CC(=CN(C)C2=O)C2=C(CO)C(=CC=C2)N2C=CC3=CC(=CC(F)=C3C2=O)C2CC2)C=C1
  Pathways:Angiogenesis
  Receptor:BTK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 62 mg/mL warmed (102.19 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Xu D, et al. J Pharmacol Exp Ther, 2012, 341(1), 90-103.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting