• Product NameAVN944
• Brief DescriptionInhibitors
• Purification99.30%
• Biological ActivityAVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
• Target NameDehydrogenase inhibitor
• CAS No. 297730-17-7
• Calculated MW 477.51
• Formulation C25H27N5O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC[C@H](CC#N)OC(=O)N[C@@H](C)C1=CC(=CC=C1)NC(=O)NC2=CC(=C(C=C2)C3=CN=CO3)OC
  Pathways:Metabolism
  Receptor:IMPDH
  Boling pt:
  Melting pt:
  Solubility:DMSO: 58 mg/mL
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zimmermann AG, et al. Prog Nucleic Acid Res Mol Biol. 1998;61:181-209.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting