• Product NameWHI-P154
• Brief DescriptionInhibitors
• Purification98.03%
• Biological ActivityWHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.
• Target NameEGFR inhibitor; JAK inhibitor; Src inhibitor; VEGFR inhibitor
• CAS No. 211555-04-3
• Calculated MW 376.2
• Formulation C16H14BrN3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(OC)C=C2C(NC3=CC(Br)=C(O)C=C3)=NC=NC2=C1
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Stem Cells
  Receptor:EGFR; JAK3; Src; VEGFR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 75 mg/mL (199.36 mM)
  Appearance:Purple-Brown Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. O'Donoghue ML, et al. J Thromb Thrombolysis. 2012 Jul;34(1):36-43.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting