• Product NameZM 323881 hydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.
• Target NameEGFR inhibitor; FGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 193000-39-4
• Calculated MW 411.86
• Formulation C22H19ClFN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.CC1=CC(F)=C(NC2=NC=NC3=C2C=CC(OCC2=CC=CC=C2)=C3)C=C1O
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; FGFR1; PDGFRβ; VEGFR1; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mg/mL (24.28 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Whittles CE, et al. Microcirculation, 2002, 9(6), 513-522.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting