• Product NameGDC-0941
• Brief DescriptionInhibitors
• Purification99.97%
• Biological ActivityPictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 957054-30-7
• Calculated MW 513.64
• Formulation C23H27N7O3S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CS(=O)(=O)N1CCN(CC2=CC3=C(S2)C(=NC(=N3)C2=C3C=NNC3=CC=C2)N2CCOCC2)CC1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTOR; p110α; p110β; p110γ; p110δ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 44 mg/mL (85.66 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Folkes AJ, et al. J Med Chem, 2008, 51(18), 5522-5532.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting