• Product NameDefactinib (VS-6063, PF-04554878)
• Brief DescriptionInhibitors
• Purification99.80%
• Biological ActivityDefactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
• Target NameFAK inhibitor
• CAS No. 1073154-85-4
• Calculated MW 510.49
• Formulation C20H21F3N8O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CNC(=O)C1=CC=C(NC2=NC=C(C(NCC3=NC=CN=C3N(C)S(C)(=O)=O)=N2)C(F)(F)F)C=C1
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:FAK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 5 mg/mL warmed (9.79 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kang Y, et al. J Natl Y Inst. 2013, 105(19), 1485-1495.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting