• Product NameGDC-0032
• Brief DescriptionInhibitors
• Purification99.62%
• Biological ActivityGDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.
• Target NamePI3K inhibitor
• CAS No. 1282512-48-4
• Calculated MW 460.53
• Formulation C24H28N8O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)N1N=C(C)N=C1C1=CN2CCOC3=C(C=CC(=C3)C3=CN(N=C3)C(C)(C)C(N)=O)C2=N1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 7 mg/mL warmed (15.19 mM); DMSO: 70 mg/mL warmed (151.99 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ndubaku CO, et al. J Med Chem. 2013 Jun 13; 56(11): 4597-610.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting