• Product NamePF 573228
• Brief DescriptionInhibitors
• Purification96.58%
• Biological ActivityPF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.
• Target NameFAK inhibitor
• CAS No. 869288-64-2
• Calculated MW 491.49
• Formulation C22H20F3N5O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CS(=O)(=O)C1=CC=CC(CNC2=NC(NC3=CC4=C(NC(=O)CC4)C=C3)=NC=C2C(F)(F)F)=C1
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:FAK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 26 mg/mL (52.9 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Slack-Davis JK, et al. J Biol Chem, 2007, 282(20), 14845-14852.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting