• Product NamePF-4708671
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
• Target NameS6 Kinase inhibitor
• CAS No. 1255517-76-0
• Calculated MW 390.41
• Formulation C19H21F3N6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCC1=CN=CN=C1N1CCN(CC2=NC3=C(N2)C=C(C=C3)C(F)(F)F)CC1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:p70 S6K
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 8 mg/mL (20.49 mM); DMSO: 30 mg/mL (76.84 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pearce LR, et al. Biochem J, 2010, 431(2), 245-255.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting