• Product NameOmecamtiv mecarbil (CK-1827452)
• Brief DescriptionInhibitors
• Purification98.75%
• Biological ActivityOmecamtiv mecarbil (CK-1827452) is the first potent cardiac myosin activator that can specifically activate the cardiac myosin S1 domain but not other muscle myosins. In clinical trials, omecamtiv mecarbil has been considered as a promising therapeutic approach to treat systolic heart failure1.
• Target NameATPase activator
• CAS No. 873697-71-3
• Calculated MW 401.43
• Formulation C20H24FN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:COC(=O)N1CCN(CC2=C(F)C(NC(=O)NC3=CN=C(C)C=C3)=CC=C2)CC1
  Pathways:Membrane transporter/Ion channel
  Receptor:ATPase
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 6 mg/mL (14.94 mM); DMSO: 80 mg/mL (199.28 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Anderson RL, et al. Mol Bio Cell, 2005, 16.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting