• Product NameRQ00203078
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.
• Target NameTRP/TRPV Channel antagonist
• CAS No. 1254205-52-1
• Calculated MW 554.85
• Formulation C21H13ClF6N2O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC(=O)C1=CC=C(C=C1)S(=O)(=O)N(CC1=CC=C(OC(F)(F)F)C=C1)C1=C(Cl)C=C(C=N1)C(F)(F)F
  Pathways:Membrane transporter/Ion channel
  Receptor:TRPM8
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chaussade C, et al. Biochem J, 2007, 404(3), 449-58.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting