• Product NameLY294002
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityLY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation.
• Target NamePI3K inhibitor
• CAS No. 154447-36-6
• Calculated MW 307.34
• Formulation C19H17NO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:O=C1C=C(OC2=C1C=CC=C2C1=CC=CC=C1)N1CCOCC1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:p110α; p110β; p110δ
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 21 mg/mL (68.32 mM); DMSO: 36 mg/mL (117.13 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ohmi M, et al. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5364-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting