• Product NameCZC-54252
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively.
• Target NameLRRK2 inhibitor
• CAS No. 1191911-27-9
• Calculated MW 504.39
• Formulation C22H25ClN6O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.COC1=C(NC2=NC=C(Cl)C(NC3=CC=CC=C3NS(C)(=O)=O)=N2)C=CC(=C1)N1CCOCC1
  Pathways:Autophagy
  Receptor:LRRK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mM
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liu F, et al. J Pharmacol Exp Ther, 2008, 327(3), 827-839.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting