• Product NameISRIB
• Brief DescriptionInhibitors
• Purification99.93%
• Biological ActivityISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.
• Target NameERK inhibitor
• CAS No. 548470-11-7
• Calculated MW 451.34
• Formulation C22H24Cl2N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:ClC1=CC=C(OCC(=O)NC2CCC(CC2)NC(=O)COC2=CC=C(Cl)C=C2)C=C1
  Pathways:MAPK
  Receptor:PERK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sidrauski C, et al. Elife. 2013, 2, e00498.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting