• Product NameWHI-P180
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityWHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
• Target NameCDK inhibitor; EGFR inhibitor
• CAS No. 211555-08-7
• Calculated MW 297.31
• Formulation C16H15N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(OC)C=C2C(NC3=CC(O)=CC=C3)=NC=NC2=C1
  Pathways:Angiogenesis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:CDK2; EGFR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. An R, et al. Pharm Res. 2009 Feb;26(2):449-58.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting