• Product NameBML-277
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBML-277 (C 3742) is a selective Chk2 (checkpoint kinase 2) inhibitor with an IC50 of 15 nM.
• Target NameChk inhibitor
• CAS No. 516480-79-8
• Calculated MW 363.8
• Formulation C20H14ClN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:NC(=O)C1=CC2=C(C=C1)N=C(N2)C1=CC=C(OC2=CC=C(Cl)C=C2)C=C1
  Pathways:Cell Cycle/Checkpoint
  Receptor:Chk2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Arienti KL, et al. J Med Chem. 2005 Mar 24; 48(6): 1873-85.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting