• Product NameWHI-P258
• Brief DescriptionInhibitors
• Purification99.59%
• Biological ActivityWHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK binding negative control in the development of new therapeutics.
• Target NameEGFR inhibitor; JAK inhibitor
• CAS No. 21561-09-1
• Calculated MW 281.31
• Formulation C16H15N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(OC)C=C2C(NC3=CC=CC=C3)=NC=NC2=C1
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Stem Cells
  Receptor:EGFR; JAK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: <1.2mg/mL
  Appearance:Faint Yellow Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fry DW, et al. Science. 1994, 265(5175), 1093-1095.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting