• Product NameTH588
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.
• Target NameMTH1 inhibitor
• CAS No. 1609960-31-7
• Calculated MW 429.52
• Formulation C24H27N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=NC(=CC(NC2CC2)=N1)C1=C(Cl)C(Cl)=CC=C1
  Pathways:DNA Damage/DNA Repair
  Receptor:MTH1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 1 mg/mL warmed (3.38 mM); DMSO: 20 mg/mL warmed (67.75 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting