• Product NameGSK923295
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. Phase 1.
• Target NameKinesin inhibitor
• CAS No. 1088965-37-0
• Calculated MW 592.13
• Formulation C32H38ClN5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@H](C1=CC=CN2C1=NC(=C2)C3=CC=C(C=C3)C[C@@H](CNC(=O)CN(C)C)NC(=O)C4=CC(=C(C=C4)OC(C)C)Cl)O
  Pathways:Cytoskeletal Signaling
  Receptor:CENP-E
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (168.88 mM); DMSO: 100 mg/mL (168.88 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wood KW, et al. Proc Natl Acad Sci U S A, 2010, 107(13), 5839-5844.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting