• Product NameWHI-P131
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityJanex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 _mu_M); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases.
• Target NameJAK inhibitor
• CAS No. 202475-60-3
• Calculated MW 297.31
• Formulation C16H15N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(OC)C=C2C(NC3=CC=C(O)C=C3)=NC=NC2=C1
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK3; JAK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sudbeck EA, et al. Clin Y Res. 1999 Jun;5(6): 1569-82.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting