• Product NameAG-1478
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
• Target NameEGFR inhibitor; HER inhibitor; PDGFR inhibitor
• CAS No. 153436-53-4
• Calculated MW 315.75
• Formulation C16H14ClN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(OC)C=C2C(NC3=CC(Cl)=CC=C3)=NC=NC2=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; HER2; PDGFR
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 13 mg/mL (41.17 mM); DMSO: 25 mg/mL (79.17 mM)
  Appearance:Faint Yellow Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Levitzki A, et al. Science, 1995, 267(5205), 1782-1788.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting