• Product NameLY-364947
• Brief DescriptionInhibitors
• Purification99.96%
• Biological ActivityLY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
• Target NameCasein Kinase inhibitor; MLK inhibitor; TGF-beta/Smad inhibitor; TNF inhibitor
• CAS No. 396129-53-6
• Calculated MW 272.3
• Formulation C17H12N4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:N1N=CC(=C1C1=CC=CC=N1)C1=CC=NC2=CC=CC=C12
  Pathways:Metabolism; Apoptosis; MAPK; Stem Cells
  Receptor:CK1δ; MLK-7K; TGFβRI; TGFβRII; RIPK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 1 mg/mL (3.67 mM)
  Appearance:Faint Yellow Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Li HY, et al. J Med Chem, 2006, 49(6), 2138-2142.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting