• Product NameGS967
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 μM, respectively.
• Target NameSodium Channel inhibitor
• CAS No. 1262618-39-2
• Calculated MW 347.22
• Formulation C14H7F6N3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FC(F)(F)OC1=CC=C(C=C1)C1=CN2C(C=C1)=NN=C2C(F)(F)F
  Pathways:Membrane transporter/Ion channel
  Receptor:late?INa?,isolated hearts; late?INa?,ventricular myocytes
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Belardinelli L, et al. J Pharmacol Exp Ther. 2013 Jan;344(1):23-32.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting