• Product NamePF-06447475
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
• Target NameLRRK2 inhibitor
• CAS No. 1527473-33-1
• Calculated MW 305.33
• Formulation C17H15N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:N#CC1=CC(=CC=C1)C1=CNC2=C1C(=NC=N2)N1CCOCC1
  Pathways:Autophagy
  Receptor:G2019S LRRK2; LRRK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: > 10 mM
  Appearance:Faint Pink Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Henderson JL, et al. J Med Chem. 2014 Nov 17.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting