• Product NameADX 47273
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityADX-47273 is a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
• Target NameGluR agonist
• CAS No. 851881-60-2
• Calculated MW 369.36
• Formulation C20H17F2N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1C[C@@H](CN(C1)C(=O)C2=CC=C(C=C2)F)C3=NC(=NO3)C4=CC=C(C=C4)F
  Pathways:Neuroscience
  Receptor:mGluR5
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 30 mg/mL (81.22 mM); DMSO: 74 mg/mL (200.34 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Minami I, et al. Cell Rep, 2012, 2(5), 1448-1460.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting