• Product NameAltiratinib(DCC2701)
• Brief DescriptionInhibitors
• Purification99.39%
• Biological ActivityAltiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.
• Target Namec-Met/HGFR inhibitor; Tie-2 inhibitor; VEGFR inhibitor
• CAS No. 1345847-93-9
• Calculated MW 510.46
• Formulation C26H21F3N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:FC1=CC=C(NC(=O)C2(CC2)C(=O)NC2=CC(F)=C(OC3=CC(NC(=O)C4CC4)=NC=C3)C=C2F)C=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Met; Tie-2; VEGFR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Pink-Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kwon Y, et al. Oncogene. 2015 Jan 8;34(2):144-53.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting