• Product NameLR-510444
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.
• Target NameMicrotubule Associated inhibitor
• CAS No. 1233948-35-0
• Calculated MW 368.47
• Formulation C19H16N2O2S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=CC=C(C=C1)S(=O)(=O)NC1=C(C)C=CC(=C1)C1=CC=C(S1)C#N
  Pathways:Cytoskeletal Signaling
  Receptor:Microtubule disruptor
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Risinger AL, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):652-60.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting