• Product NameAPY0201
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAPY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2; a unique small molecular IL-12/23 production inhibitor.
• Target NamePI3K inhibitor
• CAS No. 1232221-74-7
• Calculated MW 413.48
• Formulation C23H23N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=CC=CC(=C1)/C=N/NC2=NC3=CC(=NN3C(=C2)N4CCOCC4)C5=CC=NC=C5
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PIKfyve
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hayakawa N, et al. Bioorg Med Chem. 2014 Jun 1;22(11):3021-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting