• Product NameAG18
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.
• Target NameEGFR inhibitor
• CAS No. 118409-57-7
• Calculated MW 186.17
• Formulation C10H6N2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OC1=C(O)C=C(C=C(C#N)C#N)C=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 37 mg/mL (198.74 mM); DMSO: 37 mg/mL (198.74 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gazit A, et al. J Med Chem, 1989, 32(10), 2344-2352.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting