• Product NameSemaxinib(SU 5416)
• Brief DescriptionInhibitors
• Purification96.09%
• Biological ActivitySemaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 _mu_M, 20-fold more selective for VEGFR than PDGFR_beta_, lack of activity against EGFR, InsR and FGFR.
• Target NameVEGFR inhibitor
• CAS No. 204005-46-9
• Calculated MW 238.28
• Formulation C15H14N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:Flk1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fong TA, et al. Y Res, 1999, 59(1), 99-106.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting