• Product NameMK1775
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityMK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.
• Target NameWee1 inhibitor
• CAS No. 955365-80-7
• Calculated MW 500.6
• Formulation C27H32N8O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CC1)C1=CC=C(NC2=NC=C3C(=O)N(CC=C)N(C3=N2)C2=CC=CC(=N2)C(C)(C)O)C=C1
  Pathways:Cell Cycle/Checkpoint
  Receptor:Wee1
  Boling pt:
  Melting pt:
  Solubility:Water: 0.0001 mg/mL (0.0 mM); DMSO: 80 mg/mL (159.8 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hirai H, et al. Mol Y Ther, 2009, 8(11), 2992-3000.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting