• Product NameGSK126
• Brief DescriptionInhibitors
• Purification99.31%
• Biological ActivityGSK126 is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other human methyltransferases.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1346574-57-9
• Calculated MW 526.67
• Formulation C31H38N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC[C@H](C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
  Pathways:Chromatin/Epigenetic
  Receptor:EZH2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 3 mg/mL warmed (5.69 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. McCabe MT, et al. Nature. 2012, 492(7427), 108-112.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting