• Product NameLCL161
• Brief DescriptionInhibitors
• Purification99.72%
• Biological ActivityLCL161, a SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). Phase 2.
• Target NameIAP inhibitor
• CAS No. 1005342-46-0
• Calculated MW 500.63
• Formulation C26H33FN4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
  Pathways:Apoptosis
  Receptor:cIAP
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 20 mg/mL warmed (39.94 mM); DMSO: 100 mg/mL (199.74 mM)
  Appearance:Faint Yellow Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Weisberg E, et al. Leukemia, 2010, 24(12), 2100-2109.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting