• Product NameLY2409881 trihydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLY2409881 trihydrochloride is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.
• Target NameIκB/IKK inhibitor
• CAS No. 946518-60-1
• Calculated MW 594.43
• Formulation C24H32Cl4N6OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:Cl.Cl.Cl.CN1CCN(CCCNC2=NC=C(Cl)C(=N2)C2=CC3=C(C=CC=C3S2)C(=O)NC2CC2)CC1
  Pathways:NF-κb
  Receptor:IKK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 20 mg/mL warmed (33.64 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Deng C, et al. Clin Y Res. 2015, 21(1):134-145.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting