• Product NameCDK4-IN-1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively.
• Target NameCDK inhibitor
• CAS No. 1256963-02-6
• Calculated MW 440.97
• Formulation C22H29ClN8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)C1=C(C(Cl)=NN1)C1=NC(NC2=NC=C(C=C2)N2CCC(CC2)N(C)C)=NC=C1
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK4; Cyclin D1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Faint Yellow Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cho YS, et al. J Med Chem. 2010 Nov 25;53(22):7938-57.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting