• Product NamePI3065
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR.
• Target NameDNA-PK inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 955977-50-1
• Calculated MW 506.64
• Formulation C27H31FN6OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:FC1=C(C2=C(NC=C2)C=C1)C1=NC2=C(SC(CN3CCN(CC4CC4)CC3)=C2)C(=N1)N1CCOCC1
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK; mTOR; p110α; p110β; p110δ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 50 mg/mL warmed (98.68 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ali K, et al. Nature. 2014 Jun 19;509(7505):407-11.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting